During 1 077 299 person-years of follow-up, there were 22 798 CVD events (12142 in sub-optimal responders and 10656 inoptimal responders).
The rate of CVD was 22.6 and 19.7 per 1000 person-years for sub-optimal and optimal responders, respectively.
Patients with a sub-optimal response, compared to those with an optimal response, were significantly more likely to have an incident CVD event (crude HR 1.17, 95% CI 1.13 to 1.20; p<0.001).
After adjusting for age and baseline untreated LDL-C value, the risk of CVD remained significantly greater in sub-optimal responders compared with optimal responders (adjusted HR 1.22, 95%CI 1.19 to 1.25; p<0.001).
A competing risk approach resulted in lower but similar sub-HRs for incidence of CVD for both unadjusted (1.13, 95% CI 1.10 to 1.16; p<0.001) and adjusted (1.19, 95% CI 1.16 to 1.23; p<0.001) cumulative incidence function, as shown in figure 2.
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