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Thread: Lifetime Impact of Cows Milk on Overactivation of mTORC1

  1. #1

    Default Lifetime Impact of Cows Milk on Overactivation of mTORC1

    Lifetime Impact of Cows Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration
    Insulin
    Insulinotropic BCAAs of milk are released by milk protein hydrolysis in the intestine and induce postprandial hyperinsulinemia.
    That is why the insulinemic index of milk is three times higher than milks glycemic index.
    Predominantly, whey protein-derived amino acids released after fast intestinal hydrolysis are responsible for the insulinemic effect of milk. Insulin and IGF-1 synergistically activate PI3K-AKT-mTORC1 signaling, growth, and anabolism.
    We know from Bella Mitochondria's paper high insulin depletes vitamin d and magnesium.
    Higher vitamin d levels are required to inhibit the mTORC1 signaling.
    Vitamin D A new player in the world of mTOR signaling
    the ability of 1,25(OH)2D to induce DDIT4 and suppress mTOR may further extend the therapeutic applications of vitamin D to include a role as a potential anti-aging factor.
    Epidermal mTORC1 Signaling Contributes to the Pathogenesis of Psoriasis and Could Serve as a Therapeutic Target
    It could be that inhibition of mTORC1 signalling is the route by which some of vitamin d benefits are obtained. Vitamin D associated with reduced mortality in psoriasis patients. Maintaining natural 25(OH)D status 46-60ng/ml 115-150nol/l is critical to help to improve health of psoriasis patients.

    From the paper at the first link we see
    "Since the Neolithic revolution, over 10,000 years of preferentially fermented milk (yogurt, cheese) were the predominant milk products consumed by humans. Recent evidence has suggested that microbial fermentation of milk attenuates milk-mediated mTORC1 signaling, extensively reviewed elsewhere"
    It is pretty easy to make your own yoghurt at home or kefir if you prefer. It also means cheese is fine.

    Perhaps we ought to think about making our own fermented butter and cream if we knew where to get raw milk/cream at a reasonable price.

  2. #2

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    Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling
    Decanoic acid is Capric acid which is easily found in coconut oil
    Low-glucose and -insulin conditions, associated with ketogenic diets, can reduce the activity of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, potentially leading to a range of positive medical and health-related effects.
    Here, we determined whether mTORC1 signaling is also a target for decanoic acid, a key component of the medium-chain triglyceride (MCT) ketogenic diet.
    Using a tractable model system, Dictyostelium, we show that decanoic acid can decrease mTORC1 activity, under conditions of constant glucose and in the absence of insulin, measured by phosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1).
    We determine that this effect of decanoic acid is dependent on a ubiquitin regulatory X domain-containing protein, mediating inhibition of a conserved Dictyostelium AAA ATPase, p97, a homolog of the human transitional endoplasmic reticulum ATPase (VCP/p97) protein.
    We then demonstrate that decanoic acid decreases mTORC1 activity in the absence of insulin and under high-glucose conditions in ex vivo rat hippocampus and in tuberous sclerosis complex (TSC) patient-derived astrocytes.
    Our data therefore indicate that dietary decanoic acid may provide a new therapeutic approach to down-regulate mTORC1 signaling.
    It's likely that curcumin and berberine are also useful for inhibiting mTORC1 signaling.
    The role of curcumin in aging and senescence: Molecular mechanisms
    Scholar google search for berberine mTORC1 signaling.
    Last edited by TedHutchinson; 22nd March 2021 at 02:15 PM.

  3. #3

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    Thanks Ted.
    Gilli - DLTBGYD but more importantly KCHO

  4. #4

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    I wonder whether goats milk etc has also been studied....
    Started again on 1 September 2020. Hoping this time Im in it for the long term!

  5. #5

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    Interesting.

    I do make my own yoghurt from raw cows milk.

    I try to get unpasteurized cheese when I can. Not sure whether it's better though.

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